CBD, the cannabinoid that has been called the “Most Valuable Player,” is all the rage right now. Due in large part to the fact that it is now legal to do so, CBD derived from hemp has entered the mainstream. Hemp-CBD products can be purchased virtually anywhere, from the internet to physical storefronts.
CBD, like its popular teammates, interacts with the endocannabinoid system, and studies focusing on this topic are heating up. The medicinal, wellness and mental health applications of CBD are just beginning to be explored.
Difference Between Cannabidiol and Cannabigerol (CBG)
CBG and CBD are both non-intoxicating cannabinoids derived from the cannabis plant, but they operate in somewhat different ways. Some examples are as follows.
The molecular structure CBG vs CBD of a cannabinoid is defined as the quantity and arrangement of its constituent oxygen, carbon, and hydrogen atoms; CBG and CBD have distinct molecular structures. CBG and CBD have various three-dimensional forms due to their dissimilar molecular structures; as a result, they connect with the body’s cannabinoid receptors (CB1 and CB2) in different ways and exert diverse effects. The degree of a cannabinoid’s solubility in water and its bioavailability (how well it is eventually absorbed and used by the body) are both influenced by its molecular structure.
On a pharmacological level, CBG and CBD both have distinct effects on your receptors. CBG and CBD were both tested as agonists or activators of the 5-HT1A serotonin receptor in a study conducted in 2011, but their effects were examined in a different context. But CBG acts like an antagonist or blocker at the 5-HT1A receptor. The results demonstrated that CBG pretreatment prevented the anti-emetic effects of CBD, indicating that these two cannabinoids bind to the same site but had opposite effects at this receptor. Amazing, right?
Another intriguing distinction between CBG and CBD is the role it plays in stimulating appetite. Doses of CBG induced hyperphagia in rats, with the small animals consuming more than twice their baseline food intake. In separate research, CBG did not alter eating habits, but it did considerably lower overall food consumption.
Should You Combine CBG And CBD?
A growing corpus of research demonstrates the beneficial effects of even a single cannabinoid. However, there is a mountain of evidence indicating that the advantages are greatly amplified when many cannabinoids enter the bloodstream at once. We call this multiplicative dynamic between members of an organization the “Entourage Effect.” The theory underlying this remarkable occurrence is that a synergistic combination of cannabinoids is more effective than any of them alone.
CBG, CBD, and the entire family of cannabinoids, as well as other medicinal substances that cannabis and hemp plants generate, still have a lot to teach us. CBG and CBD, which interact with the endocannabinoid system and provide a wide range of amazing advantages, are likely to gain increasing attention in the future years.